Biomedical sciences publications

Since this is the first ligand containing the trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist pharmacophore to have affinity for the NOP receptor, we explored the structural determinants of its NOP binding affinity.

Here, the comprehensive preclinical pharmacological profile of basimglurant is presented with a focus on its therapeutic potential for MDD and drug-like properties.

This study aimed to assess the interaction between physiological sleep and reproductive hormone measures in perimenopausal women.

The aim of this study was to investigate the mechanism of action underlying the nicotine-suppressive effects of AT-1001.

A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus.

The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches.

The purpose of this study was to examine the metabolism and pharmacokinetics of 4R as part of its preclinical development as a neuroprotective drug.

In this study, we characterized two broadly HIV-neutralizing agents, human monoclonal antibody 2G12 and Galanthus nivalis lectin (GNA), for their viral targeting activities.

BOF attendees are asked to bring materials from their classes and be ready to discuss multiple viewpoints about topics, pedagogical strategies and readings from a rich history of research in…

Here we report the first discovery of an epistatic network of residues that controls the onset of terpene cyclization in Artemisia annua.

Because of the enormous complexity of the phenomena involved, it is unlikely that any single area of study can provide a clear understanding of the relative biological effectiveness of different…

Cortical interneurons, immunoreactive for neuronal nitric oxide synthase (nNOS) and the receptor NK1, express the functional activity marker Fos selectively during sleep. NREM sleep ‘pressure’ is hypothesized to accumulate...