Biomedical sciences publications
-
Nicotine Dependence as a Moderator of Genetic Influences on Smoking Cessation Treatment Outcome
In this secondary analysis of clinical trial data, we examined nicotine dependence severity as a moderator of the effects of 1198 single nucleotide polymorphisms (SNPs) in 53 biologically-relevant gene regions…
-
Design of a Peptide Inhibitor of Tyrosine Kinase 2
The development of antisense peptide inhibitors is a relatively unexplored area of research, and here we investigate inhibitory peptides specific for the Janus-associated kinase (JAK) family member, tyrosine kinase 2 (TYK2).
-
GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy
We evaluated the effects of chronic administration of GHB and the GABA B agonist R -baclofen ( R -BAC) on arousal state and cataplexy in two models of narcolepsy: orexin/ataxin-3…
-
The Adaptor Protein SAP Regulates Type II NKT-Cell Development, Cytokine Production, and Cytotoxicity against Lymphoma
Here, using a type II NKT-cell TCR transgenic mouse model, we demonstrated that CD1d-expressing hematopoietic cells, but not thymic epithelial cells, meditate efficient selection of type II NKT cells.
-
Poor Autonomic Nervous System Functioning During Sleep in Recently Detoxified Alcohol-Dependent Men and Women
We investigated nighttime ANS functioning, and the relation between ANS activity and severity of alcohol dependence in chronic alcoholism.
-
Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function
The sleep disorder narcolepsy results from loss of hypothalamic orexin/hypocretin neurons. Although narcolepsy onset is usually postpubertal, current mouse models involve loss of either orexin peptides or orexin neurons from…
-
Synchrony of Anterior Cingulate Cortex and Insular-Striatal Activation Predicts Ambiguity Aversion in Individuals with Low Impulsivity
To test how dACC functional network connectivity would be modulated by uncertainty and differ between individuals, 24 healthy participants underwent functional MRI in 3 sequential runs: 1 resting-state and 2…
-
Comparison of the Neutral Wind Seasonal Variation from Midlatitude Conjugate Observations
The seasonal variation of F region neutral wind from the midlatitude conjugate Fabry-Perot interferometer observations has been studied.
-
No Association between Germline Variation in Catechol-O-Methyltransferase and Colorectal Cancer Survival in Postmenopausal Women
Because catechol-O-methyltransferase (COMT; 22q11.21) activity is an important component of estrogen-mediated carcinogenesis, we hypothesized that germline variation in COMT may be associated with CRC survival.
-
Designing Bifunctional NOP Receptor-Mu-Opioid Receptor Ligands from NOP-Receptor Selective Scaffolds. Part II
We describe a continuing structure–activity relationship (SAR) study of the NOP-selective piperidin-4-yl-1,3-dihydroindol-2-one scaffold, to obtain bifunctional activity at MOP, and a suitable ratio of NOP/MOP agonist activity that produces a…
-
Sudemycin E Influences Alternative Splicing and Changes Chromatin Modifications
To determine the effect on gene expression, we performed genome-wide array analysis. Sudemycin E first causes a rapid change in alternative pre-messenger RNA splicing, which is later followed by changes…
-
Maternal Nutrition at Conception Modulates DNA Methylation of Human Metastable Epialleles
We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. Our results demonstrate that maternal nutritional status during…