Biomedical sciences publications
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Reduced Quality of Life When Experiencing Menstrual Pain in Women with Primary Dysmenorrhea
We investigated whether QoL varies between women with and without severe primary dysmenorrhea, and whether QoL is impaired only during menstruation or also during pain-free phases of the menstrual cycle.
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HPLC Method Development, Validation and Impurity Characterization for an Antitumor Hsp90 Inhibitor-PU-H71 (NSC 750424)
An HPLC method for the assay of the heat shock protein 90 inhibitor, PU-H71 (NSC 750424), has been developed and validated.
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Glyco-Epitope Diversity: An Evolving Area of Glycomics Research and Biomarker Discovery
Tumor glycomics research in recent years has uncovered a large panel of tumor-associated carbohydrate antigens and evidence of immune recognition of tumor-derived aberrant carbohydrates.
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Computational Models for Neglected Diseases: Gaps and Opportunities
Here, we identify gaps in which computational approaches have been used for some neglected diseases and not others. We also make recommendations for the broad-spectrum integration of these techniques into…
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Developments in Purification Methods for Obtaining and Evaluation of Collagen Derived Endogenous Angioinhibitors
This review focuses on the method developments in obtaining biologically active NC1 domains and for specific evaluations in different scenarios.
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Radiation Drugs – Still a Hot Topic
On the occasion of the second anniversary of the Fukushima disaster, it was reported inScience magazine that evacuees were still waiting to go home, but fortunately that radionuclide exposure, at…
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Working Memory Impairment and Cardiovascular Hyperarousal in Young Primary Insomniacs
We investigated memory performance and cardiovascular activity in 13 primary insomniacs (PI) compared to 13 good sleepers (GS).
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(R,R’)-4′-Methoxy-1-Naphthylfenoterol Targets GPR55-Mediated Ligand Internalization and Impairs Cancer Cell Motility
Here, we investigated the role of MNF in GPR55 signaling in human HepG2 and PANC-1 cancer cell lines in culture by focusing first on internalization of the fluorescent ligand Tocrifluor…
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Rat Strain Differences in Brain Structure and Neurochemistry in Response to Binge Alcohol
Here, alcohol-preferring (P) and alcohol-nonpreferring (NP) rats systematically bred from heterogeneous stock Wistar rats for differential alcohol drinking behavior were compared with Wistar rats to determine whether genetic divergence and…
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Vapor Pressure of Thiodiglycol
The new TDG vapor pressure data are in sharp contrast to widely accepted values from previous literature.
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Biological Barriers and Current Strategies for Modifying Nanoparticle Bioavailability
This paper reviews the anatomy of the primary organs (kidney, liver, and spleen) responsible for nanoparticle bioelimination and the components of the innate immune system (complement system and scavenger receptors)…
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Biomarkers in Pharmacology and Drug Discovery
The relative utility of single biomarkers compared to biomarker panels is discussed, along with paradigms for biomarker development, the latter in the context of three large-scale biomarker consortia, the Critical…