Biomedical sciences publications

Additive risk models are necessary for understanding the joint effects of exposures on individual and population disease risk. Yet technical challenges have limited the consideration of additive risk models in…

The in vitro release of drugs from the optimized gel formulation in simulated vaginal fluid was characterized using in-line Franz diffusion cell with regenerated cellulose membrane.

We used in vivo microdialysis and HPLC analysis to examine cortical adenosine (ADO) levels following BF microinjections of ZOL (0.6 µg/0.2 µl), ALM (1.0 µg/0.2 µl), or VEH (aCSF) combined…

We have utilized a combination of methodologies that collectively enable time-lapse imaging of CA1 neuronal calcium dynamics in behaving mice over periods of many weeks.

Loss of DJ-1 function contributes to pathogenesis in Parkinson’s disease. Here, we investigate the impact of aging and DJ-1 deficiency in mice.

Since α4a5β2 nAChRs are also predominantly on striatal dopamine terminals, these data suggest that drugs targeting α4β2 nAChRs may reduce L-dopa-induced dyskinesias in late stage Parkinson’s disease.

The issues covered here will aid in task development and utilization across species as well as reinforcing the positive role preclinical research can have in developing procognitive treatments for psychiatric…

In this study, single-time-point chemical shift imaging data were acquired from rat brain in vivo. [5-13C]Glutamate, [1-13C]acetylcarnitine and [1-13C]citrate were detected in addition to resonances from [2-13C]Pyr and [2-13C]Lac.

Here, we investigated whether nicotinic acetylcholine receptor (nAChR) agonists reduced LIDs in nonhuman primates.