Biomedical sciences publications
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Parathyroid Hormone (PTH) and PTH-Related Peptide Domains Contributing to Activation of Different PTH Receptor-Mediated Signaling Pathways
In the present investigation, a collection of PTH(1-34) and PTHrP(1-34) peptide analogs were evaluated in orthogonal human PTH1R (hPTH1R) functional assays capturing Gs- and Gq-signaling, β-arrestin recruitment, ERK1/2 phosphorylation, and receptor…
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Acute Ethanol Reduces Reversal Cost in Discrimination Learning by Reducing Perseverance in Adolescent Rhesus Macaques
The cognitive impact of acute alcohol exposure includes deficits in discrimination and reversal learning, but traditional experimental approaches make it difficult to distinguish the effect of alcohol on discrimination learning…
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Cardiac Autonomic Activity During Sleep in Recently Sober Alcoholics
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Longitudinal Changes in Sleep EEG and Brain Structure in Adolescence
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Wernicke-Korsakoff Syndrome: A Nutritional Alcohol-Related Brain Disorder
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Antileishmanial Activity of Natural Product-Like Naphthoquinones
The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from Bignoniaceae is presented.
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Structure and Function of Parkin E3 Ubiquitin Ligase Reveals Aspects of RING and HECT Ligases
Here we present the 1.58 Å structure of Parkin-R0RBR, revealing the fold architecture for the four RING domains, and several unpredicted interfaces.
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Interleukin-6 Gene Polymorphism (−174 G/C) is Associated with Toxoplasmic Retinochoroiditis
This study suggests that the genotypes related with a lower production of IL-6 may be associated with the occurrence of TR.
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Implicit Alcohol-Related Associations Affect Decision-Making in Abstinent Alcoholics
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Intrinsic Functional Connectivity in Alcoholism: Test-Retest Stability and Normalization with Sobriety
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Importance of the Nicotinic Acetylcholine Receptor System in the Prefrontal Cortex
In this work we review, in light of the latest findings, how nicotinic agonists may be acting in the PFC to influence cognitive function.
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In Vivo Measurement of Aldehyde Dehydrogenase-2 Activity in Rat Liver Ethanol Model Using Dynamic MRSI of Hyperpolarized [1-(13) C] Pyruvate
In this work, we show that dynamic MRSI of hyperpolarized pyruvate and its conversion to [1-13C]lactate can provide an indirect in vivo measurement of ALDH2 activity via the concentration of NADH.