Biomedical sciences publications
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The Nicotine-Mediated Decline in L-Dopa-Induced Dyskinesias Is Associated with a Decrease in Striatal Dopamine Release
This study investigates whether nicotine may exert its beneficial effects by modulating pre-synaptic dopaminergic function.
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Comorbidity of Alcoholism, HIVInfection and Hepatitis C: In Vivo Brain Imaging
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Biomarkers—an Essential Tie That Binds the Future of Drugs and Diagnostics
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Alzheimer’s Disease Biomarkers: More Than Molecular Diagnostics
This review assesses progress in a number of areas of AD biomarker discovery and development, constituting a potential systems approach to understanding and diagnosing this disease.
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Assessment of Cardiac Biomarkers in Cynomolgus Macaques
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Serum Biomarkers Reveal Long-Term Cardiac Injury in Isoproterenol-Treated African Green Monkeys
We have used filter-aided sample preparation (FASP) and tandem mass tag (TMT) labeling to investigate serum protein alterations in isoproterenol-treated African green monkeys.
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Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
The current study was designed to evaluate the hypnotic and cataplexy-inducing efficacy of a Hcrt antagonist in an animal model with low Hcrt tone and compare the ALM efficacy profile…
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Discovery of a Splicing Regulator Required for Cell Cycle Progression
Here we describe a new G1 mutant from an ancient family of apicomplexan protozoans. Toxoplasma gondii temperature-sensitive mutant 12-109C6 conditionally arrests in the G1 phase due to a single point mutation in…
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Nicotinic Acetylcholine Receptor Variation and Response to Smoking Cessation Therapies
Objective: To evaluate the association of nAChR single nucleotide polymorphism with abstinence in trials of smoking cessation therapies.
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Alpha7 Neuronal Nicotinic Receptors as a Drug Target in Schizophrenia
Preclinical and clinical data suggest that neuronal α7nAChRs play an important role in cognitive functions. Moreover, some, but not all, early clinical trials conducted with α7nAChR agonists show cognitive benefits…
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Immunoregulatory Profile of Monocytes from Cutaneous Leishmaniasis Patients and Association with Lesion Size
We evaluated peripheral blood CD14+ monocytes for the expression of immunoregulatory cytokines, co-stimulatory molecules and TLR9 from cutaneous leishmaniasis patients infected with L. braziliensis and noninfected individuals.
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The Twin Research Registry at SRI International
Twins in the TRR have participated in studies of complex, clinically relevant phenotypes that would not be feasible to measure in larger samples.