Biomedical sciences publications
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Alpha 6 Beta 2*and Alpha 4 Beta 2*Nicotinic Acetylcholine Receptors as Drug Targets for Parkinson’s Disease
Here we review nAChRs with particular emphasis on the subtypes that contribute to basal ganglia function. Accumulating evidence suggests that drugs targeting α6β2* and α4β2* nAChR may prove useful in…
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From Biology to Inspiration and Back: Is the Pallidal Complex a Reservoir?
This paper explores parallels between Reservoir Computing models and basal ganglia nuclei including the subthalamic nucleus and globus pallidus.
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In Situ Determination of Total Dissolved Inorganic Carbon By Underwater Membrane Introduction Mass Spectrometry
Factors affecting the response of the membrane introduction mass spectrometer (MIMS) system were examined to optimize calibrations and enhance the accuracy of component ocean carbon system measurements.
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Sheet-Like White Matter Fiber Tracts: Representation, Clustering, and Quantitative Analysis
We introduce an automated and probabilistic method for subject-specific segmentation of sheet-like fiber tracts.
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Sleep EEG, the Clearest Window Through Which to View Adolescent Brain Development
The paper by Tarokh and colleagues in this issue of SLEEP highlights how longitudinal sleep EEG data is arguably the optimal functional measure of these structural brain changes.
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Utility of a Brief Instrument for Assessing Alcohol Tolerance in Social Drinkers
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A Comparison of in Vivo Neurochemical Sequelae of Binge Alcohol Exposure in Wild-Type Wistar, Alcohol Preferring, and Alcohol Nonpreferring Rats
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A High-Throughput Fluorescence Polarization Assay for Inhibitors of Gyrase B
The assay performed with an average Z′ factor of 0.80 and was able to identify GyrB inhibitors from a screening library.
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Relationship Between Circulating Platelet Counts and Ductus Arteriosus Patency After Indomethacin Treatment
In contrast to the evidence in mice, low circulating platelet counts do not affect permanent ductus closure (or ductus reopening) in human preterm infants.
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Functional and Anatomical Remapping of Corticocerebellar Loops in Alcoholism
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Independent Contributions of Cortical Gray Matter, Aging, Sex and Alcoholism to K-Complex Amplitude Evoked During Sleep
The amplitude of the N550 component derived from the averaged evoked K-complex decreases with normal aging and with alcoholism. The study was designed to determine whether these declines are related…
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Recommendations for the Validation of Flow Cytometric Testing During Drug Development: I Instrumentation
This paper presents a consensus methodological approach that the authors have used successfully to ensure data integrity in flow cytometric studies conducted during drug development.