Biomedical sciences publications
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Ubiquitin Accumulation in Autophagy-Deficient Mice Is Dependent on the Nrf2-Mediated Stress Response Pathway: a Potential Role for Protein Aggregation in Autophagic Substrate Selection
We show that tissue-specific disruption of the essential autophagy genes Atg5 and Atg7 leads to the accumulation of all detectable Ub–Ub topologies, arguing against the hypothesis that any particular Ub linkage serves as a…
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β2 Adrenergic Receptor Agonists Inhibit the Proliferation of 1321N1 Astrocytoma Cells
Experiments were conducted to determine whether the β2-AR agonist (R,R′)-fenoterol and other β2-AR agonists could attenuate mitogenesis and, if so, by what mechanism.
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Diffusion Tensor Imaging in Aging and Age-Related Neurodegenerative Disorders
This chapter reviews evidence for changes in normal aging as the context for establishing abnormalities marking neurological and psychiatric conditions...
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The Rational Design of a Novel Potent Analogue of the 5′-AMP-Activated Protein Kinase Inhibitor Compound C with Improved Selectivity and Cellular Activity
We have designed and synthesized analogues of compound C, a non-specific inhibitor of 5′-AMP-activated protein kinase (AMPK), using a computational fragment-based drug design (FBDD) approach.
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EMX2 Is Epigenetically Silenced and Suppresses Growth in Human Lung Cancer
In this study, we found that EMX2 was dramatically downregulated in lung cancer tissue samples and this downregulation was associated with methylation of the EMX2 promoter.
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Inherited Polymorphisms in the RNA-Mediated Interference Machinery Affect MicroRNA Expression and Lung Cancer Survival
Single-nucleotide polymorphisms (SNPs) in genes involved in miR biogenesis may affect miR expression in lung tissue and be associated with lung carcinogenesis and progression.
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Bacillus Endospore Resistance to Gas Dynamic Heating
This novel laboratory approach to study the interaction of endospores with shock waves provides an experimental means to investigate the mechanisms of endospore resistance to rapid heating.
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Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature
Various methoxy- and hydroxy-substituted dibenz[c,e]oxepines were prepared via the copper(I)-induced coupling of ether-tethered arylstannanes ...
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Signs of Preclinical Wernicke’s Encephalopathy and Thiamine Levels as Predictors of Neuropsychological Deficits in Alcoholism Without Korsakoff’s Syndrome
The purpose of this study was to determine whether meeting historical criteria for unsuspected Wernicke's encephalopathy explains why some alcoholics have severe neuropsychological deficits.
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Novel α3β4 Nicotinic Acetylcholine Receptor-Selective Ligands. Discovery, Structure-Activity Studies, and Pharmacological Evaluation
We report the discovery and SAR of a novel class of compounds that bind to the α3β4 nAChR and have no measurable affinity for the α4β2 or α7 subtype.
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Novel Alpha 3 Beta 4 Nicotinic Acetylcholine Receptor-Selective Ligands. Discovery, Structure-Activity Studies, and Pharmacological Evaluation
We report the discovery and SAR of a novel class of compounds that bind to the α3β4 nAChR and have no measurable affinity for the α4β2 or α7 subtype.
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Opioid Pharmacogenomics Using a Twin Study Paradigm: Methods and Procedures for Determining Familial Aggregation and Heritability
This ongoing study takes advantage of the twin paradigm to estimate the genetic and environmental contributions to inter-individual differences in opioid responses.