Biomedical sciences publications
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RG3487, A Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents
Cumulative evidence from these studies indicates RG3487 is a novel and potent α7nAChR partial agonist that improves cognitive performance and sensorimotor gating.
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A Parallel Chiral-Achiral Liquid Chromatographic Method for the Determination of the Stereoisomers of Ketamine and Ketamine Metabolites in the Plasma and Urine of Patients with Complex Regional Pain Syndrome
A parallel chiral/achiral LC–MS/MS assay has been developed and validated to measure the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in complex regional pain syndrome…
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Measurement of Serum, Liver, and Brain Cytokine Induction, Thiamine Levels, and Hepatopathology in Rats Exposed to a 4-Day Alcohol Binge Protocol
This study aimed to determine whether binge EtOH exposure would induce the expression of certain cytokines in blood, liver, or brain, thereby supporting the neuroinflammation hypothesis of elevated Cho.
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Gene-Environment Interactions in Parkinson’s Disease and Other Forms of Parkinsonism
The application of emerging genomic technologies, such as Genome Wide Association Studies (GWAS), will certainly further our knowledge of Parkinson's disease (PD)-related genes.
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Contributions of Studies on Alcohol Use Disorders to Understanding Cerebellar Function
This overview proposes that disruption of an executive frontocerebellar network is a major contributor to characteristic behaviors of alcoholism that, on the one hand, enable alcohol use disorders, and on…
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Novel Inhibitor of Influenza Non-Structural Protein 1 Blocks Multi-Cycle Replication in an RNase L-Dependent Manner
This study demonstrated the biological mechanism for a potent new NS1 antagonist. Compound JJ3297 inhibited virus replication by more than three orders of magnitude without affecting cell viability.
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White Matter Fiber Degradation Attenuates Hemispheric Asymmetry When Integrating Visuomotor Information
We used diffusion tensor imaging tractography to examine the specific contributions of interhemispheric and intrahemispheric white matter fibers to functional measures of hemispheric transfer and parallel information processing.
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Repurposing FDA-Approved Drugs to Combat Drug-Resistant Acinetobacter Baumannii
We wanted to identify new scaffolds for drug discovery by repurposing FDA-approved drugs against Acinetobacter baumannii, an emerging Gram-negative nosocomial drug-resistant pathogen.
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A Novel Steroidal Inhibitor of Estrogen-Related Receptor alpha (ERR alpha)
We describe a novel steroidal antiestrogen that binds selectively to ERRα, but not to ERRβ or ERRγ, as determined with a resonance energy transfer assay.
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Insights from Human and Animal Neuroimaging Studies of Alcoholism
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Post-Streptococcal Auto-Antibodies Inhibit Protein Disulfide Isomerase and Are Associated with Insulin Resistance
To explore the post-streptococcal autoimmunity spectrum, we used western blot analyses, to screen healthy subjects with and without markers of recent streptococcal infections.
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Nonprofits and the Valley of Death in Drug Discovery
The research and development (R&D) process that ultimately leads to effective drugs is exceedingly difficult, and often the public does not understand the drug discovery pipeline.