Biomedical sciences publications
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Cerebral Dynamics and Metabolism of Hyperpolarized 1- 13 Cpyruvate Using Time-Resolved Mr Spectroscopic Imaging
Dynamic hyperpolarized [1-13C]pyruvate metabolic imaging in the normal anesthetized rat brain is demonstrated on a clinical 3-T magnetic resonance imaging scanner.
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Contribution of Callosal Connections to the Interhemispheric Integration of Visuomotor and Cognitive Processes
The reviewed studies on patients with callosal degradation with and without disconnection indicate a dissociation of callosal functions.
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Development and Validation of a High-Throughput Screening Assay for Human Long-Chain Fatty Acid Transport Proteins 4 and 5
The authors used mammalian cell lines stably expressing the recombinant human FATP4 and 5 and developed a high-throughput screening assay using a 96-well fluorometric imaging plate reader.
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Relationship Between Gray Matter Volume and Sleep-Specific Delta Eeg Changes in Alcoholic Men and Women
Our objective is to determine the impact of alcoholism on sleep architecture and sleep EEG power spectra in men and women with uncomplicated alcoholism.
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In Vivo Application of Sub-Second Spiral Chemical Shift Imaging (CSI) to Hyperpolarized 13C Metabolic Imaging: Comparison with Phase-Encoded CSI
A fast spiral chemical shift imaging (CSI) has been developed to address the challenge of the limited acquisition window in hyperpolarized 13C metabolic imaging.
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Volumetric Cerebral Perfusion Imaging in Healthy Adults: Regional Distribution, Laterality, and Repeatability of Pulsed Continuous Arterial Spin Labeling (PCASL)
The regional distribution, laterality, and reliability of volumetric pulsed continuous arterial spin labeling measurements of cerebral blood flow in cortical, subcortical, and cerebellar regions were determined in 10 normal volunteers studied on…
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Combining Structure and Appearance Cues for Real-Time Pedestrian Detection
We present a real-time pedestrian detection system which uses cues derived from structure and appearance classification.
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Longitudinal Study of Callosal Microstructure in the Normal Adult Aging Brain Using Quantitative DTI Fiber Tracking
We present a review of neuroimaging studies of normal adult aging conducted with diffusion tensor imaging (DTI) and data from one of the first longitudinal studies using DTI to study…
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The Right Formulation – and How to Get There
This article by Gita Shankar, PhD, Director of Formulations R&D, Pharmaceutical Sciences at SRI, describes the strategy that the company uses to develop an appropriate formulation.
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Transcallosal White Matter Degradation Detected with Quantitative Fiber Tracking in Alcoholic Men and Women: Selective Relations to Dissociable Functions
Here, we examined six anatomically defined transcallosal white matter fiber bundles and asked whether any bundle was specifically vulnerable to alcohol, what aspect of white matter integrity was most affected,…
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Incident Sleep Disordered Breathing in Old Age
We prospectively examined elderly volunteers to understand how changes in body weight are related to SDB for a period of 20–30 years.
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The SRI24 Multichannel Atlas of Normal Adult Human Brain Structure
This article describes the SRI24 atlas, a new standard reference system that was created using template-free population registration of high-resolution magnetic resonance images.