Biomedical sciences publications
-
Design of Short Linear Peptides That Show Hydrogen Bonding Constraints in Water
Using a combination of an aromatic amino acid, a homoserine side chain, and a d-amino acid, a series of linear tetrapeptides were designed that adopt an “Hse turn” in water.
-
Pharmacokinetics and Metabolism of (R,R)-Methoxyfenoterol in Rat
(R,R)-fenoterol (Fen), a beta(2)-adrenoceptor agonist, is under clinical investigation in the treatment of congestive heart disease.
-
Discovery of 1-[3-(4-Bromo-2-Methyl-2H-Pyrazol-3-Yl)-4-Methoxyphenyl]-3-(2, 4-Difluorophenyl)Urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia
We describe here a series of 5-HT2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiological measure of sleep…
-
T2 Relaxation Times of 13C Metabolites in a Rat Hepatocellular Carcinoma Model Measured in Vivo Using 13C-MRS of Hyperpolarized [1-13C]Pyruvate
Following hyperpolarized [1-13C]pyruvate injections, pyruvate and its metabolic products, alanine and lactate, were observed in the liver of five rats with hepatocellular carcinoma and five healthy control rats.
-
Hyperpolarized (13)C MRSI for Therapeutic Response Monitoring of Prostate Cancer to Radiotherapy
In this technique, the transient fate of pyr and its downstream metabolites lactate (lac), alanine, and bicarbonate is measured with 13C Magnetic Resonance Spectroscopy Imaging (MRSI) following an injection of hyperpolarized…
-
In Situ Chemical Analyses By Underwater Mass Spectrometry
-
Cytokine Measurements in a Mouse Vaginal Irritation Model for the Safety Evaluation of Microbicides
-
MicroRNA Expression Differentiates Histology and Predicts Survival of Lung Cancer
We investigated whether microRNA (miR) expression profiles can differentiate histologic subtypes and predict survival for non–small cell lung cancer.
-
Shewanella knowledgebase: integration of the experimental data and computational predictions suggests a biological role for transcription of intergenic regions
The Shewanella knowledgebase was established in 2005 to provide a framework for integrated genome-based studies on Shewanella ecophysiology.
-
Binge Ethanol Treatment Is Insufficient to Elevate Cytokine Levels Measured in Rat Blood, Liver, and Brain
-
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized By Abnormalities in PDGFRA, IDH1, EGFR, and NF1
We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.
-
Disrupted Frontocerebellar Networks in Alcoholics Revealed By Resting State Functional Connectivity Imaging