Biomedical sciences publications
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Quantitative Fiber Tracking of Lateral and Interhemispheric White Matter Systems in Normal Aging: Relations to Timed Performance
Using our quantitative fiber tracking approach, we assessed fiber tract integrity of samples of major white matter cortical, subcortical, interhemispheric, and cerebellar systems (11 bilateral and 2 callosal) on DTI…
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Global Reemergence of Tuberculosis: Are Host Defense Peptides an Option to Ameliorate Disease Burden?
Intermittent drug therapy due to noncompliance or poor delivery of therapy promotes the emergence of bacterial strains showing resistance to multiple drugs and the rise of extremely drug-resistant strains.
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Discovery of 1-[3-(4-Bromo-2-Methyl-2H-Pyrazol-3-Yl)-4-Methoxyphenyl]-3-(2, 4-Difluorophenyl)Urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia
We describe here a series of 5-HT2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiological measure of sleep…
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T2 Relaxation Times of 13C Metabolites in a Rat Hepatocellular Carcinoma Model Measured in Vivo Using 13C-MRS of Hyperpolarized [1-13C]Pyruvate
Following hyperpolarized [1-13C]pyruvate injections, pyruvate and its metabolic products, alanine and lactate, were observed in the liver of five rats with hepatocellular carcinoma and five healthy control rats.
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Comprehensive Evaluation of Let-Dependence of Chromosome Aberrations After Particle Radiation Exposure in Vivo
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Distinguishing Methicillin-Resistant and Sensitive Staphylococcus Aureus Using Volatile Headspace Metabolites
This proof-of-concept study used solid-phase microextraction fibers (SPME) to collect headspace vapors from a methicillin sensitive Staphylococcus aureus (MSSA) and a methicillin-resistant Staphylococcus aureus (MRSA) strain grown in vitro in liquid growth medium.
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SU11248 (Sunitinib) Directly Inhibits the Activity of Mammalian 5′-AMP-Activated Protein Kinase (AMPK)
Here we report that the chemotherapeutic drug SU11248 (sunitinib) is at least as potent an inhibitor of AMPK as compound C, which is a commonly used experimental direct inhibitor of…
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Patterns of Gene Expression in the Ductus Arteriosus Are Related to Environmental and Genetic Risk Factors for Persistent Ductus Patency
Three independent risk factors are associated with patent ductus arteriosus that fail to close during prostaglandin inhibition.
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Alcohol’s Effects on Brain and Behavior
One main area of this research has focused on the neuropsychological sequelae of alcoholism, which has resulted in the description of a pattern of sparing and impairment that provided an…
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Biomimetic Actinide Chelators: an Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-Li(1,2-HOPO) and 5-LIO(Me-3,2-HOPO)
A perspective on the preclinical development of two hydroxypyridonate actinide decorporation agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO), is presented. The chemical syntheses of both candidate compounds have been optimized for scale-up.
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Do Evoked Potential Differences Reflect a Deficit in Those Suffering a Sleep Disorder, or Resilience in Those Who Can Avoid It?
The novel approach taken by Gumenyuk and colleagues in this issue of SLEEP1 has produced interesting and novel data about SWSD, specifically, the absence of a difference in N1, the appearance…
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Graded Brain Abnormalities in Alcoholics with and Without Signs of Wernicke Encephalopathy