Biomedical sciences publications
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A Novel Peroxisome Proliferator-Activated Receptor Delta Antagonist, SR13904, has Anti-Proliferative Activity in Human Cancer Cells
The peroxisome proliferator-activated receptor delta (PPARδ) is a ligand-activated, nuclear receptor transcription factor that has a documented role in glucose and lipid homeostasis.
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A Systems Biology Network Model for Genetic Association Studies of Nicotine Addiction and Treatment
We discuss several applications of our ontology: to support interdisciplinary research by graphically representing a complex scientific theory, to facilitate meta-analysis across different studies, to highlight potential interactions, and to…
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Working and Episodic Memory in HIV Infection, Alcoholism, and Their Comorbidity: Baseline and 1-Year Follow-Up Examinations
Selective memory deficits occur in individuals with human immunodeficiency virus (HIV) infection and those with chronic alcoholism, but the potential compounded effect of these conditions is seldom considered, despite the…
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The Impact of Alcoholism on Sleep Evoked Delta Frequency Responses
The KC incidence and amplitude were negatively impacted in alcoholic men and women with exacerbation of the normal aging effects, particularly over frontal scalp regions.
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Dopamine and Opioid Gene Variants Are Associated with Increased Smoking Reward and Reinforcement Owing to Negative Mood
We explored associations of gene variants in the dopamine, opioid, and serotonin pathways with smoking reward (‘liking’) and reinforcement (latency to first puff and total puffs) as a function of negative mood…
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Zebrafish Chemical Screening Reveals an Inhibitor of Dusp6 That Expands Cardiac Cell Lineages
The dual-specificity phosphatase 6 (Dusp6) functions as a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal–regulated kinases (ERKs) 1 and 2.
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The Basics of Preclinical Drug Development for Neurodegenerative Disease Indications
Preclinical development encompasses the activities that link drug discovery in the laboratory to initiation of human clinical trials.
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Heterogeneity of Brain Dysmorphology in Human Alcoholism: Us-France Collaborative Project
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Accelerating Botulism Therapeutic Product Development in the Department of Defense
To mitigate the challenges of small-molecule drug discovery research efforts for the treatment of botulism, we propose product development tools to assist in management of the BoNT portfolio and to…
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Relevance of Iron Deposition in Deep Gray Matter Brain Structures to Cognitive and Motor Performance in Healthy Elderly Men and Women: Exploratory Findings
We tested functional correlates of an MR-based iron index in 10 healthy, elderly individuals previously reported to have a higher iron burden in the putamen and lower in the thalamus…
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Impact of Symptoms Experienced By Varenicline Users on Tobacco Treatment in a Real World Setting
This article examines reported symptoms, nonsmoking rates, and medication use among 1,018 smokers using varenicline in a randomized trial comparing three forms of behavioral support for smoking cessation (phone, Web,…
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Implications of Cytokine Gene Polymorphisms on the Orchestration of the Immune Response: Lessons Learned from Oral Diseases
Here we will discuss the importance of studies of gene polymorphism towards the identification of susceptible groups or prognostic indicators of oral disease.