Biomedical sciences publications
-
Phase I Metabolic Genes and Risk of Lung Cancer: Multiple Polymorphisms and mRNA Expression
We analyzed 25 SNPs (single nucleotide polymorphisms) in 2101 primary lung cancer cases and 2120 population controls from the Environment And Genetics in Lung cancer Etiology (EAGLE) study.
-
Meeting Report: Consensus Statement – Parkinson’s Disease and the Environment: Collaborativeon Health and the Environment and Parkinson’s Action Network (CHE PAN) Conference 26-28 June 2007
In June 2007, a multidisciplinary group of experts gathered in Sunnyvale, California, USA, to assess what is known about the contribution of environmental factors to PD.
-
SLC6A3 and Body Mass Index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
We evaluated associations between polymorphisms at the dopamine transporter gene(SLC6A3) and body mass index (BMI), among participants in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.
-
Global-Local Interference Is Related to Callosal Compromise in Alcoholism: a Behavior-DTI Association Study
We used a global–local paradigm to assess component processes of visuospatial ability and MR diffusion tensor imaging (DTI) to examine whether alcoholism-related microstructural degradation of the corpus callosum contributes to…
-
Evoked K-Complex Amplitude Is a Sensitive Marker of Adult Brain Aging
-
Adenosinergic and Dopaminergic Signaling as Targets for Wake-Promoting Therapeutics: Insights from Mouse Genetic Models
-
Neuroimaging of the Wernicke-Korsakoff Syndrome
Presented is the neuroradiological signature of acute Wernicke's encephalopathy (WE), derived from different types of magnetic resonance imaging (MRI) sequences.
-
Opioidergic Projections to Sleep-Active Neurons in the Ventrolateral Preoptic Nucleus
We hypothesized that the influence of opiates on sleep may be mediated, at least in part, by the ventrolateral preoptic nucleus (VLPO), a key cell group for producing behavioral sleep.
-
New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology
This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems levels that have advanced this field.
-
Rapid Alterations in Cortical Protein Profiles Underlie Spontaneous Sleep and Wake Bouts
Preliminary microarray analyses show that changes in behavioral state influence regional mRNA profiles; however, the impact of sleep on protein signatures is virtually unexplored. In these studies, cortical protein profiles…
-
Correlation of Population Parameters Leading to Power Differences in Association Studies with Population Stratification
We implemented a genetic model for population-based association studies with stratified samples and evaluated the impact on power with different genetic scenarios.
-
Variants in Nicotinic Receptors and Risk for Nicotine Dependence
The purpose of this study was to replicate these findings in an independent data set and more thoroughly investigate the role of genetic variation in the cluster of physically linked…