Biomedical sciences publications
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Quantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates
To identify new cardiac biomarkers, a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol (ISO) treatment.
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HTLV-1-Infected CD4+ T-Cells Display Alternative Exon Usages That Culminate in Adult T-Cell Leukemia
We hypothesized that besides quantitative transcriptional effects, HTLV-1 qualitatively modifies the pattern of cellular gene expression.
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Organic Cation Transporter Variation and Response to Smoking Cessation Therapies
We evaluated chr6q25.3 organic cation transporter gene (SLC22A1, SLC22A2, SLC22A3) variation and response to smoking cessation therapies.
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Comparative Uterotrophic Effects of Endoxifen and Tamoxifen in Ovariectomized Sprague-Dawley Rats
We evaluated endoxifen using a classic uterotrophic effects method.
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Compromised Frontocerebellar Circuitry Contributes to Nonplanning Impulsivity in Recovering Alcoholics
We tested the hypothesis that alcoholic patients would demonstrate compromised dorsal anterior cingulate cortex (dACC) -cerebellar functional connectivity when adjusting their strategies to accommodate uncertain conditions and would recruit compensatory…
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Formulation Development and Evaluation of Innovative Two-Polymer (SR-2P) Bioadhesive Vaginal Gel
The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI’s proprietary two-polymer gel platform (SR-2P).
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Magnitude of the Impact of Hot Flashes on Sleep in Perimenopausal Women
The presence of physiological hot flashes accounts for a significant proportion of total objective time awake during the night in perimenopausal women.
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Peer Status among Incarcerated Female Offenders: Associations with Social Behavior and Adjustment
Using a peer nomination technique in a sample of incarcerated females, our study is the first to examine the association between peer status and psychopathology in a correctional facility.
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Overlapping and Distinct Molecular Determinants Dictating the Antiviral Activities of Trim56 against Flaviviruses and Coronavirus
We show that TRIM56 poses a barrier to infections by yellow fever virus (YFV), dengue virus serotype 2 (DENV2), and human coronavirus virus (HCoV) OC43 but not encephalomyocarditis virus (EMCV).
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Prophylactic treatment with a novel bioadhesive gel formulation containing aciclovir and tenofovir protects from HSV-2 infection
Over-the-counter access to an inexpensive, effective topical microbicide could reduce the transmission of HIV and would increase women’s control over their health and eliminate the need to obtain their partners’…
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Tyrosine 308 Is Necessary for Ligand-Directed Gs-Biased Signaling of Beta2-Adrenoceptor
Here, using docking simulation and site-directed mutagenesis, we defined Tyr-308 as the key amino acid residue on β2-AR essential for Gs-biased signaling.
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Novel Human Radiation Exposure Biomarker Panel Applicable for Population Triage
We aimed to identify a panel of radiation-responsive plasma proteins that could be used in a point-of-care biologic dosimeter to detect clinically significant levels of ionizing radiation exposure