Biomedical sciences publications

This work raised the question whether dysregulation of this system may contribute to motor dysfunction and whether drugs targeting nicotinic acetylcholine receptors (nAChRs) may be of therapeutic benefit in movement…

We have used NMR spectroscopy to characterize an oligonucleotide stem loop structure based on the pre-element of an oncogenic microRNA, miR-21.

In this paper, we consider the roles in a biology textbook, adapt a definition of roles based on upper ontologies, and relate it to the corresponding notions in linguistics and…

This review will summarize the current state of knowledge regarding HERV-K and cancer and attempt to outline the potential mechanisms by which HERV-K could be involved in the onset and…

We investigated cardiac vagal and sympathetic activity in 13 young primary insomniacs and 14 good sleepers during nocturnal sleep.

We investigated the association between CHRNA5-A3-B4 and smoking abstinence. The rs2056527(A) allele was associated with lower abstinence with active pharmacotherapy, or with nicotine gum alone but not significantly with bupropion.

We have developed preliminary laboratory data for formation of volatile aldehydes produced by oxidatation of amino acids found in ELF exposed to HOCl. Formation of HOCl, via oxidation of chloride…

Zanamivir (Relenza™) and oseltamivir (Tamiflu(®)) are two antiviral drugs currently recommended by the CDC for treating influenza. Both are examples of the successful application of structure-based drug design strategies.

In this process, doxcycline was oxidized to the N-oxide using m-CPBA. The hydrochloride salt of the tertiary N-oxide was treated with Fe(0)/FeCl3 catalyst yielding the N-demethylated product.

Here we demonstrate that redirection of primary human T cells with a CAR containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-producing effector cells that show enhanced persistence.