Biomedical sciences publications
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Pharm GKB Summary: Dopamine Receptor D2
Dopamine is a catecholamine neurotransmitter and controls a variety of functions including cognition, emotion, locomotor activity, food intake, and endocrine system regulation in the central nervous system.
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Electrophysiological Evidence of Enhanced Performance Monitoring in Recently Abstinent Alcoholic Men
The objective of this paper is to identify electrophysiological mechanisms of such compensation that would be required to resolve response conflict.
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Neuropeptide B Induces Slow Wave Sleep in Mice
These results suggest that NPB induced physiological SWS through GPR7 and that NPB and GPR7 may have a role in modulating the occurrence of sleep and wakefulness.
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Self-Reported Depressive Symptoms Are Associated with Cognitive Compromise and Poorer Life Functioning in Alcoholism, Hiv and Their Comorbidity
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Sleep-Active Cells in the Cerebral Cortex and Their Role in Slow-Wave Activity
We recently identified neurons in the cerebral cortex that become activated during sleep episodes with high slow-wave activity (SWA).
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How Modulation of Functional Connectivity Between Limbic and Frontocerebellar Circuits from Rest to Task Enables Alcoholics to Recognize Who Is Who
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Sleep-Active Neuronal Nitric Oxide Synthase-Positive Cells of the Cerebral Cortex: a Local Regulator of Sleep?
We review the possible functions of neuronal nitric oxide synthase in regulating neuronal activity, synaptic plasticity and cerebral blood flow within the context of local sleep regulation in the cerebral…
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Aggressive and Chronic Periodontitis Correlate with Distinct Cellular Sources of Key Immunoregulatory Cytokines
We aimed to investigate the expression of adhesion molecules and the source of proinflammatory and anti-inflammatory cytokines in circulating mononuclear cells from patients with CP and AP.
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The Virulence of the Opportunistic Fungal Pathogen Aspergillus Fumigatus Requires Cooperation Between the Endoplasmic Reticulum-Associated Degradation Pathway (Erad) and the Unfolded Protein Response (Upr)
We examined the contribution of these integrated pathways to the growth and virulence of A. fumigatus, focusing on the ERAD protein DerA and the master regulator of the UPR, HacA.
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Patent Ductus Arteriosus Ligation Alters Pulmonary Gene Expression in Preterm Baboons
Ibuprofen-induced ductus closure improves pulmonary mechanics and increases alveolar surface area in premature baboons compared with baboons with a persistent patent ductus arteriosus (PDA).
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Pharmacogenetics of Smoking Cessation in General Practice: Results from the Patch Ii and Patch in Practice Trials
The results and lessons learned from this general practice-based pharmacogenetic research programme provide transportable insights at the transition to the second generation of pharmacogenetic and genomic investigations of smoking cessation…
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Glutathione Peroxidase 4 Is Associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson’s Brain
This study demonstrates an up-regulation of GPX4 in neurons of substantia nigra and association of this protein with dystrophic axons in striatum of Parkinson's brain, indicating a possible neuroprotective role.