Biomedical sciences publications
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MR Diffusion Tensor Imaging: a Window Into White Matter Integrity of the Working Brain
Here we present an overview of the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and pathological brain function.
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Vaccination of Rabbits with an Alkylated Toxoid Rapidly Elicits Potent Neutralizing Antibodies Against Botulinum Neurotoxin Serotype B
New Zealand White (NZW) rabbits were immunized with several different nontoxic botulinum neurotoxin serotype B (BoNT/B) preparations in an effort to optimize the production of a rapid and highly potent,…
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Daytime Sleepiness, Psychomotor Performance, Waking Eeg Spectra and Evoked Potentials in Women with Severe Premenstrual Syndrome
We assessed daytime sleepiness using objective and subjective measures in women with severe premenstrual syndrome (PMS) compared with women without significant premenstrual symptoms.
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Stimulation of Lateral Hypothalamic Glutamate and Acetylcholine Efflux By Nicotine: Implications for Mechanisms of Nicotine-Induced Activation of Orexin Neurons
Here, we used in vivo microdialysis to determine the effect of acute systemic or local nicotine on glutamate, acetylcholine, and GABA efflux in the LH/PFA of rats.
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Nicotinic Receptor-Mediated Reduction in L-DOPA-Induced Dyskinesias May Occur Via Desensitization
The present experiments were performed to understand the mechanisms whereby nicotine reduces l-DOPA-induced AIMs. We used a well established model of dyskinesias, l-DOPA-treated unilateral 6-hydroxydopamine-lesioned rats.
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LC/MS Characterization of Impurities and Degradation Products of a Potent Antitumor Peptidic Dimer, CU201
An HPLC method was developed, as part of a study supported by the National Cancer Institute's (NCI's) Rapid Access to Interventional Development (RAID) program, to assess the purity and stability…
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Quantitative Fiber Tracking of Lateral and Interhemispheric White Matter Systems in Normal Aging: Relations to Timed Performance
Using our quantitative fiber tracking approach, we assessed fiber tract integrity of samples of major white matter cortical, subcortical, interhemispheric, and cerebellar systems (11 bilateral and 2 callosal) on DTI…
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Global Reemergence of Tuberculosis: Are Host Defense Peptides an Option to Ameliorate Disease Burden?
Intermittent drug therapy due to noncompliance or poor delivery of therapy promotes the emergence of bacterial strains showing resistance to multiple drugs and the rise of extremely drug-resistant strains.
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Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs…
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Design of Short Linear Peptides That Show Hydrogen Bonding Constraints in Water
Using a combination of an aromatic amino acid, a homoserine side chain, and a d-amino acid, a series of linear tetrapeptides were designed that adopt an “Hse turn” in water.
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Callosal Degradation in HIV-1 Infection Predicts Hierarchical Perception: a DTI Study
We tested whether HIV-related callosal white matter degradation contributes to disruption of selective lateralized visuospatial and attention processes.
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Pharmacokinetics and Metabolism of (R,R)-Methoxyfenoterol in Rat
(R,R)-fenoterol (Fen), a beta(2)-adrenoceptor agonist, is under clinical investigation in the treatment of congestive heart disease.