Biomedical sciences publications
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Fast Parallel Spiral Chemical Shift Imaging at 3T Using Iterative Sense Reconstruction
Spiral chemical shift imaging (CSI) is a fast CSI technique that speeds up the data acquisition in comparison to conventional phase-encoded CSI by sampling the data while oscillating gradients are…
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Genes Implicated in Serotonergic and Dopaminergic Functioning Predict BMI Categories
This study addressed the hypothesis that variation in genes associated with dopamine function, serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories in young…
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Evaluation of Matrix Metalloproteinases in Atherosclerosis Using a Novel Noninvasive Imaging Approach
This study evaluated the ability of the novel gadolinium-based MRI contrast agent P947 to target MMPs in atherosclerotic plaques.
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Roles of Insulin and Transferrin in Neural Progenitor Survival and Proliferation
In the current study, we examined the requirements for NSC proliferation and survival in vitro using the neurosphere culture system.
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Frontal Callosal Fiber Integrity Selectively Predicts Coordinated Psychomotor Performance in Chronic Alcoholism
Quantitative fiber tracking with diffusion tensor imaging (DTI) provides a new approach for assessing deficits in the microstructural integrity of white matter circuits that may underlie cognitive deficits associated with…
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Volume Reconstruction By Inverse Interpolation: Application to Interleaved MR Motion Correction
We introduce in this work a novel algorithm for volume reconstruction from data acquired on an irregular grid, e.g., from multiple co-registered images.
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Differential Expression of Clock-Related Genes in the Cerebral Cortex of Inbred Mouse Strains in Response to Sleep Deprivation
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Selective 5HT2A and 5HT6 Receptor Antagonists Promote Sleep in Rats
Serotonin (5-HT) has long been implicated in the control of sleep and wakefulness. This study evaluated the hypnotic efficacy of the 5-HT6 antagonist RO4368554 (RO) and the 5-HT2A receptor antagonist MDL100907 (MDL)…
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Preclinical Development of Neuropeptide Therapeutics and Diagnostics
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The Use of a Nasal Resistance Valve to Treat Sleep Disordered Breathing
The present pilot study tests the hypothesis that the application of expiratory resistance via a nasal valve device would improve breathing during sleep in subjects with OSA and in primary…
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Disruption of Top-Down and Bottom-Up Processes in Alcoholics: a Functional Magnetic Resonance Imaging Study
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Genetic and Environmental Influences on Nicotine Pharmacokinetic and Pharmacodynamic Phenotypes