Publications
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Addition of Escherichia coli K–12 Growth-Observation and Gene Essentiality Data to the EcoCyc database
We have integrated data on the growth or nongrowth of E. coli K-12 obtained from published observations using a variety of individual media and from high-throughput phenotype microarrays into the EcoCyc database.
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Design of a Serum Stability Tag for Bioactive Peptides
Here we explored a possibility of designing a serum stability tag made of natural amino acids. We observed that a diproline motif (-Pro-Pro-) shows remarkable stability against serum endopeptidases.
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PortEco: A Resource for Exploring Bacterial Biology through High-Throughput Data and Analysis Tools
PortEco ( http://porteco.org) aims to collect, curate and provide data and analysis tools to support basic biological research in Escherichia coli.
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Update on Mixed-Salt Technology Development for CO2 Capture from Post-Combustion Power Stations
The new mixed-salt technology combines the well-known ammonia and potassium carbonate technologies with improved reaction kinetics and reduced emissions.
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Large-Scale Analogical Reasoning
In this paper, relying on a well-curated biology KB, we present a specific implementation of comparison questions inspired by a general model of analogical reasoning.
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Comparative Molecular Field Analysis of Fenoterol Derivatives Interacting with an Agonist-Stabilized Form of the β(2)-Adrenergic Receptor
The β2-adrenergic receptor (β2-AR) agonist [3H]-(R,R′)-methoxyfenoterol was employed as the marker ligand in displacement studies measuring the binding affinities (Ki values) of the stereoisomers of a series of 4′-methoxyfenoterol analogs in…
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A Tailoring Algorithm to Optimize Behavior Change
A new algorithm, developed with data from smoking cessation clinical trials and published practice guidelines, is designed to predict the likelihood of abstinence.
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Research Brief: Early Implementation of the Massachusetts Educator Evaluation Framework
SRI International and its research partners Abt Associates, Nancy Brigham Associates, and J. Koppich and Associates are evaluating the implementation of the new Massachusetts Educator Evaluation Framework.
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The Metacyc Database of Metabolic Pathways and Enzymes and the Biocyc Collection of Pathway/Genome Databases
MetaCyc (MetaCyc.org) is a universal database of metabolic pathways and enzymes from all domains of life. The pathways in MetaCyc are curated from the primary scientific literature, and are experimentally…
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Vapor Pressure of Thiodiglycol
The new TDG vapor pressure data are in sharp contrast to widely accepted values from previous literature.
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Young Youth Explore Geospatial Data for Citizenship Project: A case study
Whether in formal or informal science youths’ engagement with data, particularly raw data, is threatened when supports are insufficient for drawing meaning from the data. For example, there may be…
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Does First Step to Success Have Long-term Impacts on Student Behavior? An Analysis of Efficacy Trial Data
The purposes of this study were to assess whether effects in student behavior and academics were maintained at follow-up and to examine the relationship of implementation fidelity to outcomes.