Publications
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Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
The current study was designed to evaluate the hypnotic and cataplexy-inducing efficacy of a Hcrt antagonist in an animal model with low Hcrt tone and compare the ALM efficacy profile…
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Compound Ranking Based on a New Mathematical Measure of Effectiveness Using Time Course Data from Cell-Based Assays
This article proposes a new approach to measure drug effectiveness, which allows ranking compounds according to their toxic effects on live cells.
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Mars Organic Molecule Analyzer (MOMA) Mass Spectrometer for Exomars 2018 and Beyond
The Mars Organic Molecule Analyzer (MOMA) investigation forms a core part of the sample analysis capability of ExoMars. Its top objective is to address the main “life signs” goal of…
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A “Conditional” Sense of Fairness in Assessment
This article builds on recent research in universal design for learning (UDL), assessment design, and psychometrics to lay out the rationale for inference that is conditional on matching examinees with…
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Proteolytic Enzymes as Biomarkers of Focal Segmental Glomerulosclerosis
Here, the library was utilized to map the global proteolytic specificities of plasma samples obtained from patients with the nephrotic syndrome, known as focal segmental glomerulosclerosis (FSGS).
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Biomarkers—an Essential Tie That Binds the Future of Drugs and Diagnostics
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The Nicotine-Mediated Decline in L-Dopa-Induced Dyskinesias Is Associated with a Decrease in Striatal Dopamine Release
This study investigates whether nicotine may exert its beneficial effects by modulating pre-synaptic dopaminergic function.
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Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer
This study bridges a carbohydrate microarray discovery and a large-scale serological validation of anti-oligomannose antibodies as novel serum biomarkers of aggressive prostate cancer.
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Serum Biomarkers Reveal Long-Term Cardiac Injury in Isoproterenol-Treated African Green Monkeys
We have used filter-aided sample preparation (FASP) and tandem mass tag (TMT) labeling to investigate serum protein alterations in isoproterenol-treated African green monkeys.
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Computing Minimal Nutrient Sets from Metabolic Networks Via Linear Constraint Solving
We present a method for computationally determining alternative growth media for an organism based on its metabolic network and transporter complement.
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Legal, Technical, and Interpretational Considerations in the Forensic Analysis of Viruses
This review provides a general approach to viral forensics, especially in light of significant biodefense challenges.
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A Systematic Comparison of the MetaCyc and Kegg Pathway Databases
We present a comparison of the compound, reaction, and pathway content of MetaCyc version 16.0 and a KEGG version downloaded on Feb-27-2012...