Publications
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Lead Optimization of Antimalarial Propafenone Analogues
Careful examination of the bioavailability, pharmacokinetics, toxicology, and efficacy of this series of compounds using rodent models revealed orally bioavailable compounds that are nontoxic and suppress parasitemia in vivo.
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Flexible x-ray detector array fabricated with oxide thin film transistors
A flat panel flexible x-ray image sensor fabricated with oxide thin film transistors (TFT) is described.
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Proactive insider threat detection through graph learning and psychological context
This paper proposes an approach that combines Structural Anomaly Detection (SA) from social and information networks and Psychological Profiling (PP) of individuals.
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Hummingbird: privacy at the time of Twitter
In this paper, we assess the loss of privacy in today's Twitter-like OSNs and describe an architecture and a trial implementation of a privacy-preserving service called Hummingbird.
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A comparative study for IEEE Map Data Representation SIG
This talk reviews the existing geospatial data representations proposed by OGC (Open Geospatial Consortium).
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Through the Azerothian looking glass: mapping in-game preferences to real world demographics
Examining how in-game behavior preferences map onto real world demographics provides important empirically-derived insights into how to match game-based mechanisms to target demographic segments.
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Online gaming motivations scale: development and validation
In this paper, we describe the development and validation of an online gaming motivations scale based on a 3-factor model.
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Understanding experts’ and novices’ expertise judgment of Twitter users
This paper presents an empirical study to understand the differences between experts and novices in judging expertise of Twitter authors.
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Synthesis of a 35S-Labeled Dinucleoside Phosphorothioate Prodrug, an Orally Bioavailable Anti-HBV Agent
The 35S-labeled, dinucleoside phosphorothioate 1, an orally available agent against hepatitis B virus, was prepared in eight steps with high specific activity and radiochemical purity.
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Bulged DNA Substrates for Identifying Poxvirus Resolvase Inhibitors
We report an assay for resolvase cleavage activity based on fluorescence polarization (FP) for high-throughput screening and mechanistic studies.
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Metabolism, Pharmacokinetics, Tissue Distribution, and Stability Studies of the Prodrug Analog of an Anti-Hepatitis B Virus Dinucleoside Phosphorothioate
The preferential distribution of the dinucleotide 1 and its prodrug 2 into liver may be attributed to the presence of nucleoside phosphorothioate backbone because phosphorothioate oligonucleotides also reveal a similar…
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Nociceptin/Orphanin FQ Inhibition with SB612111 Ameliorates Dextran Sodium Sulfate-Induced Colitis
In this study, we asked whether the small molecule N/OFQ antagonist (−)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB612111) would inhibit the development of dextran sodium sulfate-induced colitis in C57BL/6 mice.