Publications
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The spliceosome is a therapeutic vulnerability in MYC-driven cancer
Here we discover that the spliceosome is a new target of oncogenic stress in MYC-driven cancers. We identify BUD31 as a MYC-synthetic lethal gene in human mammary epithelial cells, and…
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The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.
We report that the spliceosome modulator sudemycin induces selective cytotoxicity in primary chronic lymphocytic leukemia (CLL) cells when compared with healthy lymphocytes and tumor cells from other B-lymphoid malignancies, with…
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Total Exposure Study Analysis Consortium: A Cross-Sectional Study of Tobacco Exposures
The Total Exposure Study was designed to estimate levels of biomarkers of tobacco-specific and non-specific exposure and of potential harm in U.S. adult current cigarette smokers and tobacco product non-users.
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Sustainment of model demonstration projects: Findings from follow-up studies
This brief was developed as part of the Model Demonstration Coordination Center (MDCC) operated by SRI International for the U.S. Department of Education, Office of Special Education Programs.
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Automatic Spatial Planning For Machining
We present a novel spatial planning system that automatically generates machining plans with stable fixtures to fabricate complex geometries.
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Measuring the monitoring progress K-12 STEM education indicators: A road map
The National Science Foundation’s National Center for Science and Engineering Statistics produces Science and Engineering Indicators, a biennial compendium of quantitative data on U.S. and international science and engineering education…
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Effect of the rs1051730-rs16969968 variant and smoking cessation treatment: a meta-analysis
Objective- To assess if the allelic variations of rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene cluster are associated with smoking cessation after nicotine replacement therapy (NRT).
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Animal Paradigms to Assess Cognition with Translation to Humans
This chapter focuses on some promising translational cognitive paradigms for use in rodents, non-human primates, and humans.
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Cognitive Demands During Quiet Standing Elicit Truncal Tremor in Two Frequency Bands: Differential Relations to Tissue Integrity of Corticospinal Tracts and Cortical Targets
Given the complexity of sensorimotor integration invoked to maintain upright posture, the integrity of supratentorial brain structures may also contribute to quiet standing and consequently be vulnerable to interference from…
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ZEAL Mathematics Alignment Study: A Review of ZEAL Items in Relation to the Common Core State Standards
Zeal Learning Inc. contracted with SRI International’s Center for Technology in Learning to conduct an alignment study using a sample of ZEAL mathematics assessment items and the Common Core State…
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Brain Pathways to Recovery from Alcohol Dependence
The purpose of this meeting is to provide fundamental insights on brain mechanisms that contribute to the recovery from alcohol dependence. Ultimately, it is to promote studies in understanding neurobiological…
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Principals Discuss Early Implementation of the ASSISTments Online Homework Tutor for Mathematics
This report presents the findings from interviews with principals about their schools’ participation in the ASSISTments efficacy study on seventh-grade mathematics.