Biomedical sciences publications
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Sleep-Active Cells in the Cerebral Cortex and Their Role in Slow-Wave Activity
We recently identified neurons in the cerebral cortex that become activated during sleep episodes with high slow-wave activity (SWA).
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How Modulation of Functional Connectivity Between Limbic and Frontocerebellar Circuits from Rest to Task Enables Alcoholics to Recognize Who Is Who
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Sleep-Active Neuronal Nitric Oxide Synthase-Positive Cells of the Cerebral Cortex: a Local Regulator of Sleep?
We review the possible functions of neuronal nitric oxide synthase in regulating neuronal activity, synaptic plasticity and cerebral blood flow within the context of local sleep regulation in the cerebral…
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Aggressive and Chronic Periodontitis Correlate with Distinct Cellular Sources of Key Immunoregulatory Cytokines
We aimed to investigate the expression of adhesion molecules and the source of proinflammatory and anti-inflammatory cytokines in circulating mononuclear cells from patients with CP and AP.
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Patent Ductus Arteriosus Ligation Alters Pulmonary Gene Expression in Preterm Baboons
Ibuprofen-induced ductus closure improves pulmonary mechanics and increases alveolar surface area in premature baboons compared with baboons with a persistent patent ductus arteriosus (PDA).
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Pharmacogenetics of Smoking Cessation in General Practice: Results from the Patch Ii and Patch in Practice Trials
The results and lessons learned from this general practice-based pharmacogenetic research programme provide transportable insights at the transition to the second generation of pharmacogenetic and genomic investigations of smoking cessation…
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The Virulence of the Opportunistic Fungal Pathogen Aspergillus Fumigatus Requires Cooperation Between the Endoplasmic Reticulum-Associated Degradation Pathway (Erad) and the Unfolded Protein Response (Upr)
We examined the contribution of these integrated pathways to the growth and virulence of A. fumigatus, focusing on the ERAD protein DerA and the master regulator of the UPR, HacA.
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Glutathione Peroxidase 4 Is Associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson’s Brain
This study demonstrates an up-regulation of GPX4 in neurons of substantia nigra and association of this protein with dystrophic axons in striatum of Parkinson's brain, indicating a possible neuroprotective role.
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Alcohol Exposure and Nutritional Deficiency in Rat Models: Translational Neuroimaging Studies
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Effects of Rg3487 at the Alpha 7 Beta 2 Nicotinic Acetylcholine Receptor Expressed in Xenopus Oocytes
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Cerebral Blood Flow in Posterior Cortical Nodes of the Default Mode Network Decreases with Task Engagement But Remains Higher Than in Most Brain Regions
We employed 3D arterial spin labeling imaging to examine regional cerebral blood flow (CBF) during rest, a spatial working memory task, and a second rest.
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Inotropic Contractile Reserve and Response to Cardiac Resynchronization Therapy in Patients with Markedly Remodeled Left Ventricle
The aim of this study was to evaluate the role of ICR in predicting response to CRT in patients with markedly remodeled left ventricles.